Dr Tegan Cheng

BE(Mechanical(Biomedical))/BMedSc '11 PhD '16
Conjoint Associate Lecturer, Discipline of Child and Adolescent Health, Sydney Medical School
Conjoint Associate Lecturer, School of Aerospace, Mechanical and Mechatronic Engineering

J07 - Mechanical Engineering Building
The University of Sydney


Website Sydney Medical School

School of Aerospace, Mechanical and Mechatronic Engineering

Kids Research Institute

Biographical details

Dr Tegan Cheng is a biomedical engineer and scientist principally based at the Kids Research Institute at the Children's Hospital at Westmead. She works closely with clinicians, including Professor David Little, to develop novel solutions to address unmet needs in paediatrics. Her PhD focused on the use of tissue engineering strategies to address bone injuries and deficiencies. Tegan continues to research bone tissue engineering constructs, as well as the development of novel orthopaedic devices for children, the integration of 3D scanning and printing technologies into clinical practice.

Research interests

The treatment of bone disorders in children’s growing skeletons comes with unique challenges, including the need to consider their small size, fast growth and high levels of activity. Dr Tegan Cheng studies the biological impacts of bone disorders in children, and trials therapeutic and tissue engineering strategies to help the healing process.

“The main aim of my research is to help children who suffer from orthopaedic and neuromuscular disorders, including osteogenesis imperfecta, neurofibromatosis type 1, Charcot-Marie-Tooth disease and cerebral palsy.

“The current market for children’s orthopaedic implants is limited in options, with surgeons often having to make do with imperfect implants. I work with a team to develop new devices based on the current gaps in treatment.

“For example, I’m currently working on an implant for the treatment of Blount’s disease, a form of bowleg in children that gets worse over time, so intervention is required. The standard treatment for a child who’s older than about four years is to do an osteotomy (a cut in the bone) and then fix the bones in place using an external fixation frame involving pins that travel from the outer rings through the skin and muscle and into the bone. This frame needs to be worn for up to six months and requires intensive post-operative care involving visits to the surgeon, radiology, rehabilitation and the specialist care nurse.

“We’ve invented a specialised plate for the internal fixation of the osteotomy, much as other types of fractures are held together. This has the potential to transform the surgical management of Blount’s disease into a completely internal process, greatly reducing the impact of the intervention on the patient as well as the clinical burden of these patients on the healthcare system.

“I’ve always been fascinated by bones, and I’m passionate about my research because it’s so easy to see the real-world applications of it.

“I’ve been at the University of Sydney since 2007, when I started my undergraduate degrees in Biomedical Engineering and Medical Science. I now have conjoint appointments with the Medical School and the Faculty of Engineering and Information Technologies, which I think reflects the University’s understanding of the importance of multifaculty research.”

Themes

Biomedical engineering and technology

Selected publications

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Journals

  • Leblanc, E., Bellemore, J., Cheng, T., Little, D., Birke, O. (2017). Biomechanical considerations in slipped capital femoral epiphysis and insights into prophylactic fixation. Journal of Children's Orthopaedics, 11(2), 120-127. [More Information]
  • Little, D., Peacock, L., Mikulec, K., Cheng, T., Kneissel, M., Schindeler, A., Kramer, I., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
  • Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]
  • Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
  • Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]
  • Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
  • Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]
  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]
  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]

2017

  • Leblanc, E., Bellemore, J., Cheng, T., Little, D., Birke, O. (2017). Biomechanical considerations in slipped capital femoral epiphysis and insights into prophylactic fixation. Journal of Children's Orthopaedics, 11(2), 120-127. [More Information]
  • Little, D., Peacock, L., Mikulec, K., Cheng, T., Kneissel, M., Schindeler, A., Kramer, I., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
  • Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]

2016

  • Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
  • Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]

2015

  • Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
  • Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]

2014

  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]

2013

  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]

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